Protein adsorption on solid surfaces
Universität des Saarlandes
|2003||Studium der Physik und Mathematik an der Universität des Saarlandes|
|2004||Vordiplom in Mathematik|
|2005||Vordiplom in Physik|
|Diplomarbeit: “Proteinfilms: dynamics and morphology”, Universität des Saarlandes|
|2008||research assistant in Perth, Western Australia|
|2008 -||Doktorarbeit: "structure of adsorbed proteinfims", Universität des Saarlandes|
When a solution containing proteins comes in contact with a surface, the proteins adsorb to it. This process is of
great importance in many respects: The adsorption of proteins is the first step in the formation of a biofilm, a
complex network of bacteria, proteins, ... .
The formation of such a biofilm can lead to inflammations after implantations or to dental plaque. But biofilms are not just a problem in medicine. Also e.g. the shipping industry suffers from increased fuel consumption caused by biofilms on the ship hull.
Despite the relevance of this topic, many questions still remain unanswered: What are the leading forces? How do proteins change themselves and the surface by adsorption? Can we control the adsorption by smartly tailoring the surface?
By investigating the distribution of adsorbed proteins we try to get a better understanding of the adsorption process. We focus on how adsorbed proteins influence the behaviour of further adsorbing proteins. To visualize the distribution of this proteins, we use an atomic force microscope which allows us to determine the topography of the surface together with the adsorbed proteins in the solution.
Y. Schmitt, H. Hähl, C. Gilow, H. Mantz, K. Jacobs, O. Leidinger, M. Bellion, L.Santen,
"Structural evolution of protein-biofilms: Simulations and Experiments";
Biomicrofluidics, (2010) , (in print)
M. Bellion, L. Santen, H. Mantz, H. Hähl. A. Quinn. A. Nagel,
C. Gilow, C. Weitenberg, Y. Schmitt, and K. Jacobs, "Protein adsorption on
tailored substrates: Long-range forces and conformational changes"
J. Phys.: Condens. Matter 20 (2008) 404226
[ Abstract ] [ PDF ]